Rockefeller University Research Assistant, Neurobiology and Behavior in New York, New York
Job Title Research Assistant, Neurobiology and Behavior
Laboratory / Department Neurobiology and Behavior
Some of the labs work can be summarized in four steps. First we worked on the localization of hormone target neurons in the brain and discovered estrogen-binding neurons in a limbic/hypothalamic system. The discovery initially was made in rat brain, but our work on fish CNS through monkey CNS showed it to be a general vertebrate system . We followed up the histochemical findings to demonstrate consequences of hormone binding for electrophysiological activity and neuronal growth. Secondly, we then worked out the first neural circuit for a vertebrate behavior, the estrogen-dependent lordosis behavior. The lordosis behavior circuit proved that it is possible to explain how mechanisms for a vertebrate behavior work. Third, we found hormone-dependent genes in the brain . Their induction by estrogenic hormones has temporal, spatial and gender specificities appropriate to reproductive behavior. Fourth, in turn, the products of some of these hormone-dependent genes are required for hormone-dependent lordosis behavior. Taken together, these four findings showed that specific neurochemical reactions in specific parts of the brain determine a specific mammalian behavior .
The Research Assistant will work on a research project whose goal is to understand how giant neurons in the (mouse) hindbrain regulate brain alertness and attention. Responsibilities include nerve cell culture, immunocytochemistry, and animal behavior.
Bachelor's degree in science required. Must be willing to work with mice. Experience with nerve cell culture, immunohistochemistry, and animal behavior strongly preferred.
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